A Deep Learning Framework for the Prediction and Diagnosis of Ovarian Cancer in Pre- and Post-Menopausal Women

Author:

Ziyambe Blessed1ORCID,Yahya Abid2ORCID,Mushiri Tawanda3ORCID,Tariq Muhammad Usman4ORCID,Abbas Qaisar5ORCID,Babar Muhammad6ORCID,Albathan Mubarak5ORCID,Asim Muhammad7ORCID,Hussain Ayyaz8,Jabbar Sohail5ORCID

Affiliation:

1. Department of Electrical Engineering, Harare Polytechnic College, Causeway Harare P.O. Box CY407, Zimbabwe

2. Department of Electrical, Computer and Telecommunications Engineering, Botswana International University of Science and Technology, Palapye 10071, Botswana

3. Department of Industrial and Mechatronics Engineering, Faculty of Engineering & the Built Environment, University of Zimbabwe, Mt. Pleasant, 630 Churchill Avenue, Harare, Zimbabwe

4. Abu Dhabi University, Abu Dhabi 59911, United Arab Emirates

5. College of Computer and Information Sciences, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh 11432, Saudi Arabia

6. Robotics and Internet of Things Laboratory, Prince Sultan University, Riyadh 12435, Saudi Arabia

7. EIAS Data Science Laboratory, Prince Sultan University, Riyadh 12435, Saudi Arabia

8. Department of Computer Science, Quaid-i-Azam University, Islamabad 44000, Pakistan

Abstract

Ovarian cancer ranks as the fifth leading cause of cancer-related mortality in women. Late-stage diagnosis (stages III and IV) is a major challenge due to the often vague and inconsistent initial symptoms. Current diagnostic methods, such as biomarkers, biopsy, and imaging tests, face limitations, including subjectivity, inter-observer variability, and extended testing times. This study proposes a novel convolutional neural network (CNN) algorithm for predicting and diagnosing ovarian cancer, addressing these limitations. In this paper, CNN was trained on a histopathological image dataset, divided into training and validation subsets and augmented before training. The model achieved a remarkable accuracy of 94%, with 95.12% of cancerous cases correctly identified and 93.02% of healthy cells accurately classified. The significance of this study lies in overcoming the challenges associated with the human expert examination, such as higher misclassification rates, inter-observer variability, and extended analysis times. This study presents a more accurate, efficient, and reliable approach to predicting and diagnosing ovarian cancer. Future research should explore recent advances in this field to enhance the effectiveness of the proposed method further.

Funder

Deanship of Scientific Research at Imam Mohammad Ibn Saud Islamic University

Publisher

MDPI AG

Subject

Clinical Biochemistry

Reference53 articles.

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2. Epidemiology of ovarian cancer: A review;Reid;Cancer Biol. Med.,2017

3. A quantitative performance study of two automatic methods for the diagnosis of ovarian cancer;Blyuss;Biomed. Signal Process. Control.,2018

4. OVX1, Macrophage-Colony Stimulating Factor, and CA-125-II as Tumor Markers for Epithelial Ovarian Carcinoma A Critical Appraisal;Shen;Cancer Interdisciplin. Int. J. Am. Cancer Soc.,2001

5. Large Prospective Study of Ovarian Cancer Screening in High-Risk Women: CA125 Cut-Point Defined by Menopausal Status;Skates;Cancer Prev. Res.,2011

Cited by 2 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Improved Prediction of Ovarian Cancer Using Ensemble Classifier and Shaply Explainable AI;Cancers;2023-12-11

2. Deep Learning for Comparative Study of Ovarian Cancer Detection on Histopathological Images;2023 7th International Symposium on Multidisciplinary Studies and Innovative Technologies (ISMSIT);2023-10-26

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