A Case Control Study on Serum Levels of Potential Biomarkers in Male Breast Cancer Patients

Author:

Ahmed Abdelsalam Kamal Eldin,Asad Mohammed,Ahmed Monjid Ahmed Ibrahim,Asdaq Syed Mohammed BasheeruddinORCID,Mohzari Yahya,Alrashed Ahmed,Alghamdi NajwaJilan,Alrami Kholoud Nasser,Alharbi Wael Ahmed

Abstract

The global incidence of breast cancer among men is steadily growing. Despite this, compared to female breast cancer patients, there are very few studies on biomarkers in male breast cancer patients. A cross-sectional case control study was carried out to determine the serum levels of melatonin, ghrelin, dopamine, serotonin, epinephrine, and GABA in male breast cancer. All the recruited patients were obese, old, and had recently been diagnosed with the disease. They had not received any treatment for the cancer until the time of the study. Melatonin and epinephrine serum levels were significantly higher in breast cancer patients compared to their age-matched controls, whereas ghrelin, dopamine, GABA, and serotonin serum levels were lower in patients compared to the control group. The serum levels of most of the studied biomarkers in male breast cancer patients were similar to those observed in female breast cancer patients, except for serum melatonin levels.

Publisher

MDPI AG

Subject

Health, Toxicology and Mutagenesis,Public Health, Environmental and Occupational Health

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