Smallpox vaccination‐elicited antibodies cross‐neutralize 2022‐Monkeypox virus Clade II

Author:

Criscuolo Elena1ORCID,Giuliani Benedetta1ORCID,Ferrarese Roberto1ORCID,Ferrari Davide2ORCID,Locatelli Massimo3,Clementi Massimo14,Mancini Nicasio13ORCID,Clementi Nicola13ORCID

Affiliation:

1. Laboratory of Microbiology and Virology Vita‐Salute San Raffaele University Milan Italy

2. SCVSA Department University of Parma Parma Italy

3. IRCCS San Raffaele Hospital Milan Italy

4. Synlab Italia Castenedolo (BS) Italy

Abstract

AbstractSince early May 2022, some monkeypox virus (MPXV) infections have been reported from countries where the disease is not endemic. Within 2 months, the number of patients has increased extensively, becoming the most considerable MPXV outbreak described. Smallpox vaccines demonstrated high efficacy against MPXVs in the past and are considered a crucial outbreak control measure. However, viruses isolated during the current outbreak carry distinct genetic variations, and the cross‐neutralizing capability of antibodies remains to be assessed. Here we report that serum antibodies elicited by first‐generation smallpox vaccines can neutralize the current MPXV more than 40 years after vaccine administration.

Publisher

Wiley

Subject

Infectious Diseases,Virology

Reference25 articles.

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4. World Health Organization (WHO). WHO director‐general declares the ongoing monkeypox outbreak a public health emergency of international concern. 2022. Accessed November 16 2022.https://www.who.int/europe/news/item/23-07-2022-who-director-general-declares-the-ongoing-monkeypox-outbreak-a-public-health-event-of-international-concern

5. Vaccines for preventing smallpox;Metzger W;Cochrane Database Syst Rev,2007

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