Affiliation:
1. Department of Chemistry and the Manitoba Institute for Materials University of Manitoba 144 Dysart Road Winnipeg Manitoba R3T 2N2 Canada
Abstract
AbstractDehydrogenative coupling (DC) is an attractive approach to constructing new C−N bonds using alcohols as electrophiles. In ‘hydrogen‐borrowing’ variants of DC, the H2 liberated can be used to re‐hydrogenate unsaturated intermediates to produce saturated products. Here, we show how so‐generated H2 can also be used to replace fluorine atoms with hydrogens in CF3 groups in a tandem dehydrogenative coupling/hydrodefluorination process.