Organophotoredox Hydrodefluorination of Trifluoromethylarenes with Translational Applicability to Drug Discovery

Author:

Sap Jeroen B. I.1,Straathof Natan J. W.1,Knauber Thomas2ORCID,Meyer Claudio F.13,Médebielle Maurice4ORCID,Buglioni Laura5,Genicot Christophe6ORCID,Trabanco Andrés A.3ORCID,Noël Timothy5ORCID,am Ende Christopher W.2ORCID,Gouverneur Véronique1ORCID

Affiliation:

1. Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford OX1 3TA, United Kingdom

2. Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States

3. Discovery Chemistry, Janssen Research and Development, Jarama 75A, Toledo E-45007, Spain

4. Univ. Lyon, Université Lyon I, CNRS, INSA, CPE-Lyon, ICBMS, UMR 5246, 1 Rue Victor Grignard, 69622 Villeurbanne cedex, France

5. Micro Flow Chemistry and Synthetic Methodology, Department of Chemical Engineering and Chemistry, Eindhoven University of Technology, Het Kranenveld, Bldg 14, Helix, 5600 MB Eindhoven, The Netherlands

6. Global Chemistry, UCB New Medicines, UCB Biopharma Sprl, 1420 Braine-L’Alleud, Belgium

Funder

Janssen Research and Development

Engineering and Physical Sciences Research Council

Pfizer

UCB Biopharma SPRL

European Union Horizon 2020 research and innovation pro-gram

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

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