Affiliation:
1. College of Veterinary Medicine Yangzhou University Yangzhou Jiangsu China
2. Joint International Research Laboratory of Agriculture and Agri‐Product Safety of the Ministry of Education of China Yangzhou University Yangzhou Jiangsu China
3. Jiangsu Co‐innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses Yangzhou Jiangsu China
Abstract
AbstractThe potential impact of the combination of a high‐fat diet (HFD) and polystyrene nanoplastics (PS‐NPs) on fertility cannot be ignored, especially when the fertility rate is declining. However, it has not attracted considerable attention. In this study, an obese mouse model was established using an HFD, and the reproductive function of male mice was evaluated after intragastric administration of 100 μL of a 10 mg/mL PS‐NP suspension for 4 weeks. By determining the morphology and vitality of sperm and related indicators of testosterone production, it was found that PS‐NPs aggravated the destruction of sperm mitochondrial structure, decrease sperm activity, and testosterone production in HFD‐fed mice. To comprehensively analyze the injury mechanism, the integrity of the blood testicular barrier (BTB) and the function of Leydig and Sertoli cells were further analyzed. It was found that PS‐NPs could destroy BTB, promote the degeneration of Leydig cells, reduce the number of Sertoli cells, and decrease lactate secretion in HFD‐fed mice. PS‐NPs further interfered with redox homeostasis in the testicular tissues of HFD‐fed mice. This study found that PS‐NPs could aggravate the damage to the reproductive system of obese male mice by further perturbing its redox homeostasis and revealed the potential health risk of PS‐NPs exposure under an HFD.
Funder
National Key Research and Development Program of China
Priority Academic Program Development of Jiangsu Higher Education Institutions
Subject
Health, Toxicology and Mutagenesis,Management, Monitoring, Policy and Law,Toxicology,General Medicine
Cited by
1 articles.
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