Germline genetic testing for inherited prostate cancer in practice: Implications for genetic testing, precision therapy, and cascade testing

Author:

Giri Veda N.1ORCID,Hegarty Sarah E.2,Hyatt Colette1,O'Leary Erin3,Garcia John3,Knudsen Karen E.4,Kelly William K.5,Gomella Leonard G.6

Affiliation:

1. Cancer Risk Assessment and Clinical Cancer Genetics; Division of Population Science, Department of Medical Oncology; Sidney Kimmel Cancer Center; Thomas Jefferson University; Philadelphia Pennsylvania

2. Division of Biostatistics; Department of Pharmacology and Experimental Therapeutics; Sidney Kimmel Medical College; Thomas Jefferson University; Philadelphia Pennsylvania

3. Invitae; San Francisco California

4. Department of Cancer Biology; Sidney Kimmel Cancer Center; Thomas Jefferson University; Philadelphia Pennsylvania

5. Division of Solid Tumor Oncology; Department of Medical Oncology; Sidney Kimmel Cancer Center; Thomas Jefferson University; Philadelphia Pennsylvania

6. Department of Urology; Thomas Jefferson University; Philadelphia Pennsylvania

Publisher

Wiley

Subject

Urology,Oncology

Reference22 articles.

1. 2018 https://www.nccn.org/professionals/physician_gls/pdf/prostate.pdf

2. Role of genetic testing for inherited prostate cancer risk: Philadelphia Prostate Consensus Conference 2017;Giri;J Clin Oncol,2018

3. https://www.nccn.org/professionals/physician_gls/pdf/genetics_screening.pdf

4. DNA-repair defects and olaparib in metastatic prostate cancer;Mateo;N Engl J Med,2015

5. Inherited DNA-repair gene pathogenic variants in men with metastatic prostate cancer;Pritchard;N Engl J Med,2016

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