Role of Genetic Testing for Inherited Prostate Cancer Risk: Philadelphia Prostate Cancer Consensus Conference 2017
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Published:2018-02-01
Issue:4
Volume:36
Page:414-424
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ISSN:0732-183X
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Container-title:Journal of Clinical Oncology
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language:en
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Short-container-title:JCO
Author:
Giri Veda N.1, Knudsen Karen E.1, Kelly William K.1, Abida Wassim1, Andriole Gerald L.1, Bangma Chris H.1, Bekelman Justin E.1, Benson Mitchell C.1, Blanco Amie1, Burnett Arthur1, Catalona William J.1, Cooney Kathleen A.1, Cooperberg Matthew1, Crawford David E.1, Den Robert B.1, Dicker Adam P.1, Eggener Scott1, Fleshner Neil1, Freedman Matthew L.1, Hamdy Freddie C.1, Hoffman-Censits Jean1, Hurwitz Mark D.1, Hyatt Colette1, Isaacs William B.1, Kane Christopher J.1, Kantoff Philip1, Karnes R. Jeffrey1, Karsh Lawrence I.1, Klein Eric A.1, Lin Daniel W.1, Loughlin Kevin R.1, Lu-Yao Grace1, Malkowicz S. Bruce1, Mann Mark J.1, Mark James R.1, McCue Peter A.1, Miner Martin M.1, Morgan Todd1, Moul Judd W.1, Myers Ronald E.1, Nielsen Sarah M.1, Obeid Elias1, Pavlovich Christian P.1, Peiper Stephen C.1, Penson David F.1, Petrylak Daniel1, Pettaway Curtis A.1, Pilarski Robert1, Pinto Peter A.1, Poage Wendy1, Raj Ganesh V.1, Rebbeck Timothy R.1, Robson Mark E.1, Rosenberg Matt T.1, Sandler Howard1, Sartor Oliver1, Schaeffer Edward1, Schwartz Gordon F.1, Shahin Mark S.1, Shore Neal D.1, Shuch Brian1, Soule Howard R.1, Tomlins Scott A.1, Trabulsi Edouard J.1, Uzzo Robert1, Vander Griend Donald J.1, Walsh Patrick C.1, Weil Carol J.1, Wender Richard1, Gomella Leonard G.1
Affiliation:
1. Veda N. Giri, Karen E. Knudsen, William K. Kelly, Robert B. Den, Adam P. Dicker, Jean Hoffman-Censits, Mark D. Hurwitz, Colette Hyatt, Grace Lu-Yao, Mark J. Mann, James R. Mark, Peter A. McCue, Ronald E. Myers, Stephen C. Peiper, Edouard J. Trabulsi, and Leonard G. Gomella, Jefferson Sidney Kimmel Cancer Center; Justin E. Bekelman, University of Pennsylvania Perelman School of Medicine; S. Bruce Malkowicz, University of Pennsylvania; Elias Obeid and Robert Uzzo, Fox Chase Cancer Center; Gordon F....
Abstract
Purpose Guidelines are limited for genetic testing for prostate cancer (PCA). The goal of this conference was to develop an expert consensus-driven working framework for comprehensive genetic evaluation of inherited PCA in the multigene testing era addressing genetic counseling, testing, and genetically informed management. Methods An expert consensus conference was convened including key stakeholders to address genetic counseling and testing, PCA screening, and management informed by evidence review. Results Consensus was strong that patients should engage in shared decision making for genetic testing. There was strong consensus to test HOXB13 for suspected hereditary PCA, BRCA1/2 for suspected hereditary breast and ovarian cancer, and DNA mismatch repair genes for suspected Lynch syndrome. There was strong consensus to factor BRCA2 mutations into PCA screening discussions. BRCA2 achieved moderate consensus for factoring into early-stage management discussion, with stronger consensus in high-risk/advanced and metastatic setting. Agreement was moderate to test all men with metastatic castration-resistant PCA, regardless of family history, with stronger agreement to test BRCA1/2 and moderate agreement to test ATM to inform prognosis and targeted therapy. Conclusion To our knowledge, this is the first comprehensive, multidisciplinary consensus statement to address a genetic evaluation framework for inherited PCA in the multigene testing era. Future research should focus on developing a working definition of familial PCA for clinical genetic testing, expanding understanding of genetic contribution to aggressive PCA, exploring clinical use of genetic testing for PCA management, genetic testing of African American males, and addressing the value framework of genetic evaluation and testing men at risk for PCA—a clinically heterogeneous disease.
Publisher
American Society of Clinical Oncology (ASCO)
Subject
Cancer Research,Oncology
Cited by
154 articles.
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