Alcohol consumption, DNA methylation and colorectal cancer risk: Results from pooled cohort studies and Mendelian randomization analysis

Author:

Zhou Xuan1,Wang Lijuan1,Xiao Jiarui1,Sun Jing1,Yu Lili1,Zhang Han2,Meng Xiangrui3,Yuan Shuai4,Timofeeva Maria56ORCID,Law Philip J.7ORCID,Houlston Richard S.7,Ding Kefeng8ORCID,Dunlop Malcolm G.6,Theodoratou Evropi69,Li Xue1ORCID

Affiliation:

1. Department of Big Data in Health Science School of Public Health, and Center of Clinical Big Data and Analytics of The Second Affiliated Hospital Zhejiang University School of Medicine Hangzhou Zhejiang China

2. College of Public Health Zhengzhou University Zhengzhou Henan China

3. Division of Psychiatry University College of London London UK

4. Unit of Cardiovascular and Nutritional Epidemiology Institute of Environmental Medicine, Karolinska Institutet Stockholm Sweden

5. Danish Institute for Advanced Study (DIAS), Epidemiology, Biostatistics and Biodemography Research Unit, Institute of Public Health, University of Southern Denmark Odense Denmark

6. Cancer Research UK Edinburgh Centre Medical Research Council Institute of Genetics and Cancer, University of Edinburgh Edinburgh UK

7. Division of Genetics and Epidemiology The Institute of Cancer Research London UK

8. Department of Colorectal Surgery and Oncology Key Laboratory of Cancer Prevention and Intervention, Ministry of Education, The Second Affiliated Hospital, Zhejiang University Hangzhou Zhejiang China

9. Centre for Global Health Usher Institute, University of Edinburgh Edinburgh UK

Funder

Science Fund for Distinguished Young Scholars of Zhejiang Province

Publisher

Wiley

Subject

Cancer Research,Oncology

Reference46 articles.

1. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries

2. World Cancer Research Fund/American Institute for Cancer ResearchDiet Nutrition Physical Activity and Colorectal Cancer. Continuous Update Project Expert Report; 2018.http://dietandcancerreport.org. Accessed 6 August 2021.

3. Meta‐analysis of 16 studies of the association of alcohol with colorectal cancer

4. Alcohol consumption and site-specific cancer risk: a comprehensive dose–response meta-analysis

5. Moderate Alcohol Consumption and Colorectal Cancer Risk

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