DNA methylation modulates epigenetic regulation in colorectal cancer diagnosis, prognosis and precision medicine-Reference-Cited by-全球学者库

DNA methylation modulates epigenetic regulation in colorectal cancer diagnosis, prognosis and precision medicine

Published:2024-01-28 Issue:1 Volume:5 Page:34-53
ISSN:2692-3114
Container-title:Exploration of Targeted Anti-tumor Therapy
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Author:

Ye Jingxin¹^ORCID,Zhang Jianfeng²^ORCID,Ding Weifeng³^ORCID

Affiliation:

1. Department of Laboratory Medicine, Affiliated Hospital of Nantong University, Nantong 226001, Jiangsu Province, China; Department of Gastroenterology, Affiliated Hospital of Nantong University, Nantong 226001, Jiangsu Province, China; Department of Gastroenterology, The Affiliated Suqian Hospital of Xuzhou Medical University,Suqian 223800, Jiangsu Province, China

2. Department of Gastroenterology, Affiliated Hospital of Nantong University, Nantong 226001, Jiangsu Province, China

3. Department of Laboratory Medicine, Affiliated Hospital of Nantong University, Nantong 226001, Jiangsu Province, China

Abstract

Colorectal cancer (CRC) is a multifaceted disease influenced by the interplay of genetic and environmental factors. The clinical heterogeneity of CRC cannot be attributed exclusively to genetic diversity and environmental exposures, and epigenetic markers, especially DNA methylation, play a critical role as key molecular markers of cancer. This review compiles a comprehensive body of evidence underscoring the significant involvement of DNA methylation modifications in the pathogenesis of CRC. Moreover, this review explores the potential utility of DNA methylation in cancer diagnosis, prognostics, assessment of disease activity, and prediction of drug responses. Recognizing the impact of DNA methylation will enhance the ability to identify distinct CRC subtypes, paving the way for personalized treatment strategies and advancing precision medicine in the management of CRC.

Funder

National Natural Science Foundation of China

Postdoctoral Science Foundation of Jiangsu Province

Publisher

Open Exploration Publishing

Subject

Cancer Research,Oncology

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