Affiliation:
1. Department of Neurosurgery Fuzong Clinical College of Fujian Medical University, 900 Hospital Fuzhou China
2. Department of Microbiology and Immunology & Key Immunopathology Laboratory of Guangdong Province Shantou University Medical College Shantou China
3. Department of Cardiovascular Medicine Shantou University Medical College Shantou China
4. Department of Neurosurgery Affiliated Jieyang People's Hospital of Sun Yat‐sen University Jieyang China
5. Department of Neurosurgery, First Affiliated Hospital Shantou University Medical College Shantou China
Abstract
AbstractObjectiveThe aim of this study was to examine the predictive value of the multiplication of neutrophil and monocyte counts (MNM) in peripheral blood, and develop a new predictive model for the prognosis of patients with aneurysmal subarachnoid hemorrhage (aSAH).MethodsThis is a retrospective analysis that included 2 separate cohorts of patients undergoing endovascular coiling for aSAH. The training cohort consisted of 687 patients in the First Affiliated Hospital of Shantou University Medical College; the validation cohort consisted of 299 patients from Sun Yat‐sen University's Affiliated Jieyang People's Hospital. The training cohort was used to develop 2 models to predict unfavorable prognosis (modified Rankin scale of 3–6 at 3 months): one was based on traditional factors (e.g., age, modified Fisher grade, NIHSS score, and blood glucose), and another model that included traditional factors as well as MNM on admission.ResultsIn the training cohort, MNM upon admission was independently associated with unfavorable prognosis (odds ratio after adjustment, 1.06; 95% confidence interval [CI], 1.03–1.10). In the validation cohort, the basic model that included only traditional factors had 70.99% sensitivity, 84.36% specificity, and 0.859 (95% CI, 0.817–0.901) area under the receiver operating characteristic curve (AUC). Adding MNM increased model sensitivity (from 70.99% to 76.48%), specificity (from 84.36% to 88.63%), and overall performance (AUC 0.859 [95% CI, 0.817–0.901] to 0.879 [95% CI, 0.841–0.917]).InterpretationMNM upon admission is associated with unfavorable prognosis in patients undergoing endovascular embolization for aSAH. The nomogram including MNM is a user‐friendly tool to help clinicians quickly predict the outcome of patients with aSAH.
Funder
China Postdoctoral Science Foundation
National Natural Science Foundation of China
Natural Science Foundation of Guangdong Province
Subject
Neurology (clinical),General Neuroscience
Cited by
3 articles.
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