Author:
Li Tian,Zhuang Dongzhou,Xiao Yong,Chen Xiaoxuan,Zhong Yuan,Ou Xurong,Peng Hui,Wang Shousen,Chen Weiqiang,Sheng Jiangtao
Abstract
Abstract
Background
This study aimed to validate the efficacy the multiplication of neutrophils and monocytes (MNM) and a novel dynamic nomogram for predicting in-hospital death in patients with aneurysmal subarachnoid hemorrhage (aSAH).
Methods
Retrospective study was done on 986 patients with endovascular coiling for aSAH. Independent risk factors associated with in-hospital death were identified using both univariate and multivariate logistic regression analysis. In the development cohort, a dynamic nomogram of in-hospital deaths was introduced and made available online as a straightforward calculator. To predict the in-hospital death from the external validation cohort by nomogram, calibration analysis, decision curve analysis, and receiver operating characteristic analysis were carried out.
Results
72/687 patients (10.5%) in the development cohort and 31/299 patients (10.4%) in the validation cohort died. MNM was linked to in-hospital death in univariate and multivariate regression studies. In the development cohort, a unique nomogram demonstrated a high prediction ability for in-hospital death. According to the calibration curves, the nomogram has a reliable degree of consistency and calibration. With threshold probabilities between 10% and 90%, the nomogram’s net benefit was superior to the basic model. The MNM and nomogram also exhibited good predictive values for in-hospital death in the validation cohort.
Conclusions
MNM is a novel predictor of in-hospital mortality in patients with aSAH. For aSAH patients, a dynamic nomogram is a useful technique for predicting in-hospital death.
Funder
Fujian Provincial Science and Technology Innovation Joint Fund
Natural Science Foundation of Guangdong Province
China Postdoctoral Science Foundation
Publisher
Springer Science and Business Media LLC
Cited by
1 articles.
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