Affiliation:
1. College of Health Science and Environmental Engineering Shenzhen Technology University Shenzhen 518118 China
2. Jiangxi Key Laboratory of Bioprocess Engineering and Co‐Innovation Center for In‐Vitro Diagnostic Reagents and Devices of Jiangxi Province College of Life Sciences Jiangxi Science and Technology Normal University Nanchang 330013 China
3. Shenzhen Bay Laboratory Shenzhen 518132 China
Abstract
AbstractCanonical phototherapeutics have several limitations, including a lack of tumor selectivity, nondiscriminatory phototoxicity, and tumor hypoxia aggravation. The tumor microenvironment (TME) is characterized by hypoxia, acidic pH, and high levels of H2O2, GSH, and proteases. To overcome the shortcomings of canonical phototherapy and achieve optimal theranostic effects with minimal side effects, unique TME characteristics are employed in the development of phototherapeutic nanomedicines. In this review, the effectiveness of three strategies for developing advanced phototherapeutics based on various TME characteristics is examined. The first strategy involves targeted delivery of phototherapeutics to tumors with the assistance of TME‐induced nanoparticle disassembly or surface modification. The second strategy involves near‐infrared absorption increase‐induced phototherapy activation triggered by TME factors. The third strategy involves enhancing therapeutic efficacy by ameliorating TME. The functionalities, working principles, and significance of the three strategies for various applications are highlighted. Finally, possible challenges and future perspectives for further development are discussed.
Funder
National Natural Science Foundation of China
Subject
Biomaterials,Biotechnology,General Materials Science,General Chemistry
Cited by
6 articles.
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