Three Strategies in Engineering Nanomedicines for Tumor Microenvironment‐Enabled Phototherapy

Author:

He Shiliang1ORCID,Jia Xiao2,Feng Sai2,Hu Junqing13

Affiliation:

1. College of Health Science and Environmental Engineering Shenzhen Technology University Shenzhen 518118 China

2. Jiangxi Key Laboratory of Bioprocess Engineering and Co‐Innovation Center for In‐Vitro Diagnostic Reagents and Devices of Jiangxi Province College of Life Sciences Jiangxi Science and Technology Normal University Nanchang 330013 China

3. Shenzhen Bay Laboratory Shenzhen 518132 China

Abstract

AbstractCanonical phototherapeutics have several limitations, including a lack of tumor selectivity, nondiscriminatory phototoxicity, and tumor hypoxia aggravation. The tumor microenvironment (TME) is characterized by hypoxia, acidic pH, and high levels of H2O2, GSH, and proteases. To overcome the shortcomings of canonical phototherapy and achieve optimal theranostic effects with minimal side effects, unique TME characteristics are employed in the development of phototherapeutic nanomedicines. In this review, the effectiveness of three strategies for developing advanced phototherapeutics based on various TME characteristics is examined. The first strategy involves targeted delivery of phototherapeutics to tumors with the assistance of TME‐induced nanoparticle disassembly or surface modification. The second strategy involves near‐infrared absorption increase‐induced phototherapy activation triggered by TME factors. The third strategy involves enhancing therapeutic efficacy by ameliorating TME. The functionalities, working principles, and significance of the three strategies for various applications are highlighted. Finally, possible challenges and future perspectives for further development are discussed.

Funder

National Natural Science Foundation of China

Publisher

Wiley

Subject

Biomaterials,Biotechnology,General Materials Science,General Chemistry

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