Affiliation:
1. Department of Chemistry Lyallpur Khalsa College Jalandhar Punjab 144001 India
2. Department of Chemistry U.G.C. Centre of Advance Studies in Chemistry Guru Nanak Dev University Amritsar 143005 India
Abstract
AbstractEpoxide ring is considered as an efficient structural toolbox to access 1,2‐difunctionalised compounds. Epoxide precursors are highly susceptible towards nucleophiles owing to its inherent ring strain. Metal free methodologies for epoxides ring opening with various nucleophiles provide an easy, economic and sustainable access to synthetically and biologically important 1,2‐difunctionalized compounds without harming the environment. This article highlights step by step development of various strategies for the ring opening of epoxides without the use of metal from last two decades. Use of water, ionic liquids, cyclodextrins and organocatalyts for the ring opening reactions of epoxide have been discussed in detail.