1,4-Diazabicyclo[2.2.2]octane (DABCO) in Organic Synthesis and Catalysis: A Quinquennial Report (2019-to Date)

Abstract

: DABCO is one of the more effective basic organocatalysts/reagents that can be used for a range of organic transformations, including C-H functionalization, formation of hetero-hetero bonds, rearrangements, the synthesis of heterocyclic compounds, cyclizations and annulations, other miscellaneous reactions. This quinquennial review aims to critically and perceptively address noteworthy contributions of non chiral catalyst DABCO for regular organic transformations from 2019 onward. The key areas of attention were the advantages and limits of the approach, in addition to the mechanistic pathway, which is required for a specific organic transformation to be performed effectively.