Affiliation:
1. Institute of Marine Science and Technology Shandong University Qingdao 266237 China
2. State Key Laboratory of Crystal Materials Shandong University Jinan Shandong 250100 China
3. Shenzhen Research Institute of Shandong University Shenzhen 518057 China
Abstract
AbstractLow‐dimensional material field‐effect transistor (FET)‐based biosensors have the advantages of high sensitivity, high detection speed, small size, low cost, and excellent compatibility with integrated circuits. The sensing mechanism is extremely important in the design and fabrication of high‐performance FET biosensors in practical applications. Herein, an InSe‐FET biosensor is designed and its dominant sensing mechanism during detection and (mi)RNA detection performance are investigated. Finite element analysis reveals the electrostatic potential distribution in the InSe channel with DNA probe assembly showing that Coulomb scattering is the dominant sensing mechanism for carrier scattering‐sensitive InSe. The simulation and experimental results indicate that carriers in InSe are extremely sensitive to the scattering of surface impurities because of their small electron mass. The firstly reported back‐gate bias working mode of an InSe‐FET biosensor has a linear relationship with an extra‐large detectable range of 1 fM–10 nM, high specificity for identifying 1‐nucleotide polymorphisms, and excellent repeatability and reusability. The detection of biomarker miRNAs in clinical serum samples and specific RNA in SARS‐CoV‐2 pseudovirus samples indicate promising applications of InSe‐FET biosensors in critical disease screening and the fast diagnoses of infectious diseases. This study can be useful for the design and fabrication of high‐performance FET biosensors.
Funder
Major Scientific and Technological Innovation Project of Shandong Province
National Natural Science Foundation of China
Subject
Electrochemistry,Condensed Matter Physics,Biomaterials,Electronic, Optical and Magnetic Materials
Cited by
6 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献