Early administration of COVID ‐19 convalescent plasma with high titer antibody content by live viral neutralization assay is associated with modest clinical efficacy

Author:

Belov Artur1,Huang Yin1,Villa Carlos H.1,Whitaker Barbee I.1,Forshee Richard1,Anderson Steven A.1,Eder Anne1,Verdun Nicole1,Joyner Michael J.2,Wright Scott R.3,Carter Rickey E.4,Hung Deborah T.5,Homer Mary6,Hoffman Corey6,Lauer Michael7,Marks Peter1ORCID,

Affiliation:

1. Center for Biologics Evaluation and Research US FDA Silver Spring Maryland USA

2. Department of Anesthesiology and Perioperative Medicine Mayo Clinic Rochester Minnesota USA

3. Department of Cardiology and the Human Research Protection Program Mayo Clinic Rochester Minnesota USA

4. Department of Quantitative Health Sciences Mayo Clinic Jacksonville Florida USA

5. Infectious Disease and Microbiome Program Broad Institute Cambridge Massachusetts USA

6. Biomedical Advanced Research and Development Authority (BARDA) District of Columbia Washington USA

7. Office of the Director National Institutes of Health Bethesda Maryland USA

Funder

U.S. Department of Health and Human Services

Publisher

Wiley

Subject

Hematology

Reference70 articles.

1. Mild or Moderate Covid-19

2. COVID‐19 Treatement Guidelines Panel.Coronavirus Disease 2019 (COVID‐19) Treatment Guidelines. National Institutes of Health. Available at:https://www.covid19treatmentguidelines.nih.gov/. Accessed February 2022.

3. The convalescent sera option for containing COVID-19

4. Deployment of convalescent plasma for the prevention and treatment of COVID-19

5. Passive antibody therapy for infectious diseases

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