Knockdown long noncoding RNA nuclear paraspeckle assembly transcript 1 suppresses colorectal cancer through modulating miR-193a-3p/KRAS

Author:

Zhu Zhouting12ORCID,Du Shangce3,Yin Kai4,Ai Shichao1,Yu Mengchao2,Liu Yanqing2,Shen Yan1,Liu Minghui2,Jiao Ruihua2,Chen Xi2,Guan Wenxian1

Affiliation:

1. Department of General Surgery; Affiliated Drum Tower Hospital of Nanjing University Medical School; Nanjing China

2. State Key Laboratory of Pharmaceutical Biotechnology, NJU Advanced Institute for Life Sciences (NAILS), Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, School of Life Sciences; Nanjing University; Nanjing China

3. Department of General Surgery; Drum Tower Clinical Medical College of Nanjing Medical University; Nanjing China

4. Department of General Surgery; Taixing Hospital Affiliated to Yangzhou University; Taixing China

Funder

The National Key Research and Development Program of China

Government of Jiangsu Province

Publisher

Wiley

Subject

Cancer Research,Radiology, Nuclear Medicine and imaging,Oncology

Reference63 articles.

1. Cancer statistics, 2015;Siegel;CA Cancer J Clin,2015

2. Primary and secondary prevention of colorectal cancer;Tarraga Lopez;Clin Med Insights Gastroenterol,2014

3. APC and oncogenic KRAS are synergistic in enhancing Wnt signaling in intestinal tumor formation and progression;Janssen;Gastroenterology,2006

4. Targeting the PI3K signaling pathway in KRAS mutant colon cancer;Hong;Cancer Med,2016

5. Deregulation of the miR-16-KRAS axis promotes colorectal cancer;You;Sci Rep,2016

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