Geniposide downregulates the VEGF / SphK1 / S1P pathway and alleviates angiogenesis in rheumatoid arthritis in vivo and in vitro

Author:

Wang Yan1234ORCID,Wu Hong123ORCID,Deng Ran1234,Dai Xue‐jing1234ORCID,Bu Yan‐hong1234ORCID,Sun Ming‐hui1234ORCID,Zhang Heng1234ORCID,Wang Meng‐die1234ORCID,Wang Rong‐hui1234ORCID

Affiliation:

1. College of Pharmacy Anhui University of Chinese Medicine Hefei China

2. Key Laboratory of Xin'an Medicine Ministry of Education Hefei China

3. Anhui Province Key Laboratory of Research & Development of Chinese Medicine Science and Technology Department of Anhui Province Hefei China

4. Anhui Province Key Laboratory of Chinese Medicinal Formula Science and Technology Department of Anhui Province Hefei China

Funder

National Natural Science Foundation of China

Publisher

Wiley

Subject

Pharmacology

Reference57 articles.

1. Dual blockade of VEGFR1 and VEGFR2 by a novel peptide abrogates VEGF-driven angiogenesis, tumor growth, and metastasis through PI3K/AKT and MAPK/ERK1/2 pathway

2. 2010 Rheumatoid arthritis classification criteria: An American College of Rheumatology/European League Against Rheumatism collaborative initiative;Aletaha D.;Multicenter Study,2010

3. Angiogenesis and the persistence of inflammation in a rat model of proliferative synovitis

4. Computational investigation of sphingosine kinase 1 (SphK1) and calcium dependent ERK1/2 activation downstream of VEGFR2 in endothelial cells;Bazzazi H.;Hojjat Bazzazi,Aleksander S Popel,2017

5. Evaluation of therapeutic targets in animal models of arthritis: How does it relate to rheumatoid arthritis?

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