Affiliation:
1. Department of Orthopaedics University Medical Center Utrecht Utrecht University Utrecht 3584 CX The Netherlands
2. Department of Functional Materials in Medicine and Dentistry Institute of Functional Materials and Biofabrication (IFB), KeyLab Polymers for Medicine of the Bavarian Polymer Institute (BPI) University of Würzburg Pleicherwall 2 97070 Würzburg Germany
3. Department of Clinical Sciences Faculty of Veterinary Medicine Utrecht University Utrecht 3584 CT The Netherlands
Abstract
AbstractMajor challenges in biofabrication revolve around capturing the complex, hierarchical composition of native tissues. However, individual 3D printing techniques have limited capacity to produce composite biomaterials with multi‐scale resolution. Volumetric bioprinting recently emerged as a paradigm‐shift in biofabrication. This ultrafast, light‐based technique sculpts cell‐laden hydrogel bioresins into 3D structures in a layerless fashion, providing enhanced design freedom over conventional bioprinting. However, it yields prints with low mechanical stability, since soft, cell‐friendly hydrogels are used. Herein, the possibility to converge volumetric bioprinting with melt electrowriting, which excels at patterning microfibers, is shown for the fabrication of tubular hydrogel‐based composites with enhanced mechanical behavior. Despite including non‐transparent melt electrowritten scaffolds in the volumetric printing process, high‐resolution bioprinted structures are successfully achieved. Tensile, burst, and bending mechanical properties of printed tubes are tuned altering the electrowritten mesh design, resulting in complex, multi‐material tubular constructs with customizable, anisotropic geometries that better mimic intricate biological tubular structures. As a proof‐of‐concept, engineered tubular structures are obtained by building trilayered cell‐laden vessels, and features (valves, branches, fenestrations) that can be rapidly printed using this hybrid approach. This multi‐technology convergence offers a new toolbox for manufacturing hierarchical and mechanically tunable multi‐material living structures.
Funder
European Research Council
ReumaNederland
Deutsche Forschungsgemeinschaft
Subject
Mechanical Engineering,Mechanics of Materials,General Materials Science
Cited by
23 articles.
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