Affiliation:
1. School of Mechanical Medical and Process Engineering Queensland University of Technology (QUT) Brisbane 4000 Australia
2. Centre for Biomedical Technologies Queensland University of Technology (QUT) Kelvin Grove 4059 Australia
3. School of Chemical Engineering Faculty of Engineering Architecture and Information Technology University of Queensland (UQ) St Lucia 4072 Australia
Abstract
AbstractThe field of melt electrowriting (MEW) has seen significant progress, bringing innovative advancements to the fabrication of biomaterial scaffolds, and creating new possibilities for applications in tissue engineering and beyond. Multidisciplinary collaboration across materials science, computational modeling, AI, bioprinting, microfluidics, and dynamic culture systems offers promising new opportunities to gain deeper insights into complex biological systems. As the focus shifts towards personalized medicine and reduced reliance on animal models, the multidisciplinary approach becomes indispensable. This review provides a concise overview of current strategies and innovations in controlling and optimizing cellular responses to MEW scaffolds, highlighting the potential of scaffold material, MEW architecture, and computational modeling tools to accelerate the development of efficient biomimetic systems. Innovations in material science and the incorporation of biologics into MEW scaffolds have shown great potential in adding biomimetic complexity to engineered biological systems. These techniques pave the way for exciting possibilities for tissue modeling and regeneration, personalized drug screening, and cell therapies.
Funder
Advance Queensland
Australian Research Council
MTPConnect
Subject
Electrochemistry,Condensed Matter Physics,Biomaterials,Electronic, Optical and Magnetic Materials