Affiliation:
1. Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education Cancer Research Institute and School of Basic Medicine Sciences Central South University Changsha Hunan 410000 China
2. NHC Key Laboratory of Carcinogenesis and Human Key Laboratory of Cancer Metabolism Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine Central South University Changsha Hunan 410000 China
3. Department of Chemistry and Center for Fluorinated Functional Materials University of South Dakota Vermillion SD 57069 USA
Abstract
AbstractChemodynamic therapy (CDT) has emerged as an outstanding antitumor therapeutic method due to its selectivity and utilization of tumor microenvironment. However, there are still unmet requirements to achieve a high antitumor efficiency, including the tumor accumulation of catalyst and enrichment of reactants of Fenton reaction. Here, an iron‐loaded semiconducting polymer dot modified with glucose oxidase (Pdot@Fe@GOx) is reported to deliver iron ions into tumor tissues and in situ generation of hydrogen peroxide in tumors. On one hand, Pdot@Fe@GOx converts glucose to gluconic acid and hydrogen peroxide (H2O2) in tumor, which not only consumes glucose of tumor cells, but also provides the H2O2 for the following Fenton reaction. On the other hand, the Pdot@Fe@GOx delivers active iron ions in tumor to perform CDT with the combination of the generated H2O2. In addition, the Pdot@Fe@GOx has both photothermal and photodynamic effects under the irradiation of near‐infrared laser, which can improve and compensate the CDT effect to kill cancer cells. This Pdot@Fe@GOx‐based multiple‐mode therapeutic strategy has successfully achieved a synergistic anticancer effect with minimal side effects and has the potential to be translated into preclinical setting for tumor therapy.
Funder
National Natural Science Foundation of China
Subject
Pharmaceutical Science,Biomedical Engineering,Biomaterials
Cited by
1 articles.
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