Altered kynurenine pathway metabolism in autism: Implication for immune-induced glutamatergic activity

Author:

Lim Chai K.1,Essa Musthafa M.23,de Paula Martins Roberta1,Lovejoy David B.1,Bilgin Ayse A.4,Waly Mostafa I.2,Al-Farsi Yahya M.5,Al-Sharbati Marwan5,Al-Shaffae Mohammed A.6,Guillemin Gilles J.1

Affiliation:

1. Department of Biomedical Sciences, Faculty of Medicine and Health Sciences; Macquarie University; NSW Australia

2. Department of Food Science and Nutrition; Sultan Qaboos University; Sultanate of Oman

3. Ageing and Dementia Research Group; Sultan Qaboos University; Sultanate of Oman

4. Department of Statistics, Faculty of Science and Engineering; Macquarie University; NSW Australia

5. Department of Family Medicine and Public Health; Sultan Qaboos University; Sultanate of Oman

6. Department of Behavioral Medicine; Sultan Qaboos University; Sultanate of Oman

Publisher

Wiley

Subject

Genetics(clinical),Clinical Neurology,General Neuroscience

Reference65 articles.

1. Elevated serum levels of interleukin-17A in children with autism;Al-Ayadhi;Journal of Neuroinflammation,2012

2. Picolinic acid blocks the neurotoxic but not the neuroexcitant properties of quinolinic acid in the rat brain: Evidence from turning behaviour and tyrosine hydroxylase immunohistochemistry;Beninger;Neuroscience,1994

3. Decreased tryptophan metabolism in patients with autism spectrum disorders;Boccuto;Molecular Autism,2013

4. Mechanism for quinolinic acid cytotoxicity in human astrocytes and neurons;Braidy;Neurotox Research,2009

5. Increased glutamate concentration in the auditory cortex of persons with autism and first-degree relatives: A (1)H-MRS study. Autism Research: Official Journal of the International Society for Autism;Brown;Research,2013

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