Increasing both CoCrMo-alloy particle size and surface irregularity induces increased macrophage inflammasome activation in vitro potentially through lysosomal destabilization mechanisms

Author:

Caicedo Marco S.12,Samelko Lauryn13,McAllister Kyron3,Jacobs Joshua J.1,Hallab Nadim J.123

Affiliation:

1. Department of Orthopedic Surgery; Rush University Medical Center; 1735 W Harrison MC107 Chicago Illinois 60612

2. Orthopedic Analysis, LLC; Chicago Illinois 60612

3. Department of Immunology; Rush University Medical Center; Chicago Illinois 60612

Funder

National Institute of Arthritis and Musculoskeletal

Skin Diseases of the National Institutes of Health

Publisher

Wiley

Subject

Orthopedics and Sports Medicine

Reference45 articles.

1. What other biologic and mechanical factors might contribute to osteolysis;Greenfield;J Am Acad Orthop Surg,2008

2. Biologic effects of implant debris;Hallab;Bull Hosp Jt Dis,2009

3. Tumor necrosis factor-alpha/nuclear transcription factor-kappaB signaling in periprosthetic osteolysis;Schwarz;J Orthop Res,2000

4. In vitro macrophage response to polyethylene and polycarbonate-urethane particles;Smith;J Biomed Mater Res A,2010

5. Lymphocyte responses in patients with total hip arthroplasty;Hallab;J Orthop Res,2005

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