Leptin Overexpression as a Poor Prognostic Factor for Colorectal Cancer

Abstract

Leptin acts as an adipocytokine functions via the leptin receptor, which stimulates growth, migration, and invasion of cancer cells. This study is aimed at identifying leptin as a prognostic factor in colorectal cancer (CRC). The differentially expressed genes with prognostic value in CRC tissues either with or without liver metastasis were assessed based on The Cancer Genomic Atlas (TCGA). Leptin was considered a candidate gene for further analysis. Its expression features of 206 CRC patients without liver metastasis and 201 patients with metastasis on tissue microarrays were assessed by immunochemical staining, and the effect of leptin on survival was assessed by Kaplan-Meier analyses. Overexpressed leptin indicated a poorer prognosis for CRC patients in overall survival (p<0.05, log-rank test) based on the TCGA database. The leptin expression significantly correlated with metastasis stage (p<.010) and lymph node involvement (p<.010). Multivariate analysis also indicated that strong leptin expression was an independent adverse prognosticator in CRC (p=.017). Leptin may be valued as a prognostic marker could contribute to predicting a clinical outcome for patients with CRC.