Ginsenoside-Rg1 Protects the Liver against Exhaustive Exercise-Induced Oxidative Stress in Rats


Korivi Mallikarjuna1,Hou Chien-Wen1,Huang Chih-Yang23,Lee Shin-Da3,Hsu Ming-Fen1,Yu Szu-Hsien1,Chen Chung-Yu1,Liu Yung-Yang4,Kuo Chia-Hua15


1. Laboratory of Exercise Biochemistry, Department of Sports Sciences, Taipei Physical Education College, Taipei 11153, Taiwan

2. Department of Health and Nutrition Biotechnology, Asia University, Taichung 41354, Taiwan

3. Graduate Institute of Chinese Medicine, China Medical University, Taichung 40402, Taiwan

4. The Chest Department, Taipei Veterans General Hospital and School of Medicine, National Yang-Ming University, Taipei 112, Taiwan

5. Department of Physical Therapy, Graduate Institute of Rehabilitation Science, China Medical University, Taichung 40402, Taiwan


Despite regular exercise benefits, acute exhaustive exercise elicits oxidative damage in liver. The present study determined the hepatoprotective properties of ginsenoside-Rg1 against exhaustive exercise-induced oxidative stress in rats. Forty rats were assigned into vehicle and ginsenoside-Rg1 groups (0.1 mg/kg bodyweight). After 10-week treatment, ten rats from each group performed exhaustive swimming. Estimated oxidative damage markers, including thiobarbituric acid reactive substance (TBARS) (67%) and protein carbonyls (56%), were significantly (P<0.01) elevated after exhaustive exercise but alleviated in ginsenoside-Rg1 pretreated rats. Furthermore, exhaustive exercise drastically decreased glutathione (GSH) content (∼79%) with concurrent decreased superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) activities. However, these changes were attenuated in Rg1 group. Additionally, increased xanthine oxidase (XO) activity and nitric oxide (NO) levels after exercise were also inhibited by Rg1 pretreatment. For the first time, our findings provide strong evidence that ginsenoside-Rg1 can protect the liver against exhaustive exercise-induced oxidative damage.


National Science Council


Hindawi Limited


Complementary and alternative medicine







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