Affiliation:
1. Computer Science and Engineering, National Institute of Technology, Calicut, Kerala, India
2. School of Computer Science and Engineering, Vellore Institute of Technology, Vellore, Tamil Nadu, India
Abstract
Background:
Breast cancer is the most common cancer in women across the world, with
high incidence and mortality rates. Being a heterogeneous disease, gene expression profiling based
analysis plays a significant role in understanding breast cancer. Since expression patterns of patients
belonging to the same stage of breast cancer vary considerably, an integrated stage-wise analysis involving
multiple samples is expected to give more comprehensive results and understanding of breast
cancer.
Objective:
The objective of this study is to detect functionally significant modules from gene coexpression
network of cancerous tissues and to extract prognostic genes related to multiple stages of
breast cancer.
Methods:
To achieve this, a multiplex framework is modelled to map the multiple stages of breast cancer, which
is followed by a modularity optimization method to identify functional modules from it. These functional modules are
found to enrich many Gene Ontology terms significantly that are associated with cancer.
Result and Discussion:
Predictive biomarkers are identified based on differential expression analysis
of multiple stages of breast cancer.
Conclusion:
Our analysis identified 13 stage-I specific genes, 12 stage-II specific genes, and 42 stage-III specific genes
that are significantly regulated and could be promising targets of breast cancer therapy. That apart, we could identify 29,
18 and 26 lncRNAs specific to stage I, stage II and stage III respectively.
Publisher
Bentham Science Publishers Ltd.
Subject
Computational Mathematics,Genetics,Molecular Biology,Biochemistry
Cited by
7 articles.
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