Affiliation:
1. Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science and Technology, Hisar, Haryana,
125001, India
Abstract
Abstract:
Silymarin, a flavonolignan derived from the seeds extract of Silybum marianum (milk
thistle), has been frequently used since ancient times. It is made up of flavonolignans such as silychristin,
isosilybin A and B, dehydrosilybin, and silybin as well as flavonoids like taxifolin, with
silibinin being the most active. Silibinin is a diastereoisomeric combination of two flavonolignans,
silybin A and silybin B, with a diastereoisomeric structure. It is found in a variety of phytopreparations
that are used to prevent and treat liver disorders. It is considered an important component
in a huge range of cosmetic, pharmacological, and medical formulations. Several investigations
have revealed that silibinin has anticancer and chemopreventive properties, as well as hypocholesterolaemic,
antimicrobial, antidiabetic, anticancer, antihypertension, antiparkinson, antiinflammatory,
antioxidant, cardioprotective, and neuroprotective benefits by the help of different
mechanisms such as inducing apoptosis, decreasing cell proliferation, inhibiting angiogenesis and
viral transition and its entry, and also regulating insulin secretion by decreasing or increasing the
expression of sterol regulatory element binding protein-1c (SREBP-1C) and insig-1 transcription
factor, etc. Silibinin data is gathered from many public databanks in order to emphasize its important
role in the treatment or prevention of various diseases.
Funder
CSIR, Council of Scientific and Industrial Research
Publisher
Bentham Science Publishers Ltd.
Subject
General Pharmacology, Toxicology and Pharmaceutics
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