Affiliation:
1. Centre for Pharmaceutical Chemistry & Pharmaceutical Analysis, Amity Institute of Pharmacy, Amity University Uttar Pradesh, Noida-201313, Uttar Pradesh, India
Abstract
Anticancer is a high priority research area for scientists as cancer is one of the leading causes of death
globally. It is pertinent to mention here that conventional anticancer drugs such as methotrexate, vincristine,
cyclophosphamide, etoposide, doxorubicin, cisplatin, etc. are not much efficient for the treatment of different
types of cancer; also these suffer from serious side effects leading to therapy failure. A large variety of cancerrelated
receptors such as carbonic anhydrase, tyrosine kinase, topoisomerase, protein kinase, histone deacetylase,
etc. have been identified which can be targeted by anticancer drugs. Heterocycles like oxadiazole, thiazole,
thiadiazole, indole, pyridine, pyrimidine, benzimidazole, etc. play a pivotal role in modern medicinal chemistry
because they have a broad spectrum of pharmacological activities including prominent anticancer activity.
Therefore, it was considered significant to explore heterocyclic compounds reported in recent most literature
which can bind effectively with the cancer-related receptors. This will not only provide a targeted approach to
deal with cancer but also the safety profile of the drugs can be further improved. The information provided in
this manuscript may be found useful for the design and development of anticancer drugs.
Publisher
Bentham Science Publishers Ltd.
Subject
Cancer Research,Pharmacology,Molecular Medicine
Cited by
6 articles.
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