A concise review on the role of <scp>MIR100HG</scp> in human disorders-Reference-Cited by-同舟云学术

A concise review on the role of MIR100HG in human disorders

Published:2023-07-24 Issue:16 Volume:27 Page:2278-2289
ISSN:1582-1838
Container-title:Journal of Cellular and Molecular Medicine
language:en
Short-container-title:J Cellular Molecular Medi

Author:

Ghafouri‐Fard Soudeh¹^ORCID,Harsij Atefeh²,Farahzadi Hossein²,Hussen Bashdar Mahmud³,Taheri Mohammad⁴⁵,Mokhtari Majid⁶

Affiliation:

1. Department of Medical Genetics, School of Medicine Shahid Beheshti University of Medical Sciences Tehran Iran

2. Phytochemistry Research Centre Shahid Beheshti University of Medical Sciences Tehran Iran

3. Department of Clinical Analysis, College of Pharmacy Hawler Medical University Erbil Iraq

4. Urology and Nephrology Research Centre Shahid Beheshti University of Medical Sciences Tehran Iran

5. Institute of Human Genetics Jena University Hospital Jena Germany

6. Skull Base Research Centre, Loghman Hakim Hospital Shahid Beheshti University of Medical Sciences Tehran Iran

Abstract

AbstractMIR100HG is a long non‐coding RNA (lncRNA) encoded by a locus on chr11:122,028,203‐122,556,721. This gene can regulate cell proliferation, apoptosis, cell cycle transition and cell differentiation. MIR100HG was firstly identified through a transcriptome analysis and found to regulate differentiation of human neural stem cells. It is functionally related with a number of signalling pathways such as TGF‐β, Wnt, Hippo and ERK/MAPK signalling pathways. Dysregulation of MIR100HG has been detected in a diversity of cancers in association with clinical outcomes. Moreover, it has a role in the pathophysiology of dilated cardiomyopathy, intervertebral disk degeneration and pulmonary fibrosis. The current study summarizes the role of these lncRNAs in human disorders.

Publisher

Wiley

Subject

Cell Biology,Molecular Medicine

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1111/jcmm.17875

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