Prolonged anti-emetic activity and 5-HT3-receptor antagonism by BRL 46470 in conscious ferrets
Author:
Affiliation:
1. SmithKline Beecham Pharmaceuticals, Coldharbour Road, The Pinnacles, Harlow, Essex CM 19 SAD, UK
Publisher
Oxford University Press (OUP)
Subject
Pharmaceutical Science,Pharmacology
Link
http://academic.oup.com/jpp/article-pdf/46/6/520/36993480/j.2042-7158.1994.tb03843.x.pdf
Reference5 articles.
1. The anti-emetic potential of the 5-hydroxytryptamine3 receptor antagonist BRL 43694;Bermudez;Br. J. Cancer,1988
2. BRL 46470A: a highly potent, selective and long acting 5-HT3 receptor antagonist with anxiolytic-like properties;Blackburn;Psychopharmacology,1993
3. BRL 46470 potently antagonizes neural responses activated by 5-HT3 receptors;Newberry;Neuropharmacology,1993
4. The anxiolytic activity of BRL 46470 in the cynomolgus monkey;Piper;Biol. Psychiatr.,1991
5. The pharmacology of anti-emetic agents;Sanger,1993
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1. Synthesis and Development of Indole Based 5-HT3 Receptor Antagonists as Anti-Emetic Drugs in Oncology: An Update;Current Medicinal Chemistry;2021-12
2. Persisting sensitization of the behavioural response to formalin-induced injury in the rat through activation of serotonin2A receptors;Neuroscience;1997-02
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