Synthesis and Development of Indole Based 5-HT3 Receptor Antagonists as Anti-Emetic Drugs in Oncology: An Update-Reference-Cited by-同舟云学术

Synthesis and Development of Indole Based 5-HT3 Receptor Antagonists as Anti-Emetic Drugs in Oncology: An Update

Published:2021-12 Issue:42 Volume:28 Page:8733-8754
ISSN:0929-8673
Container-title:Current Medicinal Chemistry
language:en
Short-container-title:CMC

Author:

Rivera-Fonseca Johana L.¹,González-Rivas Nelly¹,Unnamatla M. V. Basavanag¹,García-Eleno Marco A.¹,Reyes Horacio²,López-Valdez L. Germán³,Corona-Becerril David¹,Cuevas-Yañez Erick¹^ORCID

Affiliation:

1. Centro Conjunto de Investigación en Química Sustentable UAEM-UNAM, Carretera Toluca-Atlacomulco Km. 14.5, Toluca, Estado de México 50200, Mexico | Facultad de Química, Universidad Autónoma del Estado de México. Paseo Colón esq. Paseo Tollocan, 50120, Toluca, Mexico

2. División de Ingeniería Química, Tecnológico de Estudios Superiores de Jocotitlán. Carretera Toluca-Atlacomulco km 44.8, Ejido de San Juan y San Agustin, Jocotitlán, Edo. México

3. Laboratorio de Productos Naturales, Área de Química, Departamento de Preparatoria Agrícola, Universidad Autónoma Chapingo, Apartado 74, Oficina de Correos Chapingo, Km 38.5 carretera México-Texcoco, Chapingo, México 56230, Mexico

Abstract

: An important group of antiemetic drugs used in the treatment of nausea and vomiting after chemotherapy containing an indole moiety in their structures, working as 5- hydroxytryptamine type 3 serotonin receptor antagonist (5-HT3). This study focuses on compounds bearing an indole core that present a 5-HT3 receptor antagonist activity, which have been successfully used as antiemetic drugs for reducing chemotherapy adverse secondary effects during cancer treatment. Their synthesis, biological activities, and some outstanding characteristics are discussed, providing a general outlook towards the development of more efficient antiemetic drugs.

Funder

SIEA-UAEMEX

CONACYT

Publisher

Bentham Science Publishers Ltd.

Subject

Pharmacology,Molecular Medicine,Drug Discovery,Biochemistry,Organic Chemistry

Cited by 3 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Synthesis, crystal structure and DFT study of tert-butyl 6-chloro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)- 1H-indole-1-carboxylate;Molecular Crystals and Liquid Crystals;2023-04-10

2. Evaluating Aprepitant single-dose plus granisetron and dexamethasone in children receiving highly emetogenic chemotherapy for the prevention of chemotherapy-induced nausea and vomiting: A triple-blinded randomized clinical trial;Hematology, Transfusion and Cell Therapy;2022-03

3. Therapeutic potential of pyrrole and pyrrolidine analogs: an update;Molecular Diversity;2022-01-25