The clinical significance ofBRAFandNRASmutations in a clinic-based metastatic melanoma cohort

Author:

Ekedahl H.1,Cirenajwis H.23,Harbst K.23,Carneiro A.24,Nielsen K.56,Olsson H.24,Lundgren L.24,Ingvar C.17,Jönsson G.23

Affiliation:

1. Department of Surgery; Lund University; Lund 22185 Sweden

2. Department of Oncology; Lund University; Lund 22185 Sweden

3. CREATE Health Strategic Center for Translational Cancer Research; Lund University; Lund Sweden

4. Department of Oncology; Skåne University Hospital; Lund Sweden

5. Department of Dermatology; Clinical Sciences Lund; Lund University; Lund 22185 Sweden

6. Department of Dermatology; Helsingborg General Hospital; Helsingborg Sweden

7. Department of Surgery; Skåne University Hospital; Lund Sweden

Publisher

Wiley

Subject

Dermatology

Reference24 articles.

1. Frequencies of BRAF and NRAS mutations are different in histological types and sites of origin of cutaneous melanoma: a meta-analysis;Lee;Br J Dermatol,2011

2. Targeting the MAPK pathway in melanoma: why some approaches succeed and other fail;Inamdar;Biochem Pharmacol,2010

3. Improved survival with vemurafenib in melanoma with BRAF V600E mutation;Chapman;N Engl J Med,2011

4. NRAS mutation status is an independent prognostic factor in metastatic melanoma;Jakob;Cancer,2012

5. NRAS and BRAF mutations arise early during melanoma pathogenesis and are preserved throughout tumor progression;Omholt;Clin Cancer Res,2003

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