Folate-decorated hydrophilic three-arm star-block terpolymer as a novel nanovehicle for targeted co-delivery of doxorubicin and Bcl-2 siRNA in breast cancer therapy

Author:

Qian Junmin,Xu Minghui,Suo Aili,Xu Weijun,Liu Ting,Liu Xuefeng,Yao Yu,Wang Hongjie

Funder

National Natural Science Foundation of China

Project of Natural Science Foundation of Shaanxi Province, China

Fundamental Research Funds for the Central Universities

Publisher

Elsevier BV

Subject

Molecular Biology,Biomedical Engineering,Biochemistry,Biomaterials,General Medicine,Biotechnology

Reference56 articles.

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3. Doxorubicin treatment in vivo causes cytochrome C release and cardiomyocyte apoptosis, as well as increased mitochondrial efficiency, superoxide dismutase activity, and Bcl-2:Bax ratio;Childs;Cancer Res,2002

4. Biofunctional self-assembled nanoparticles of folate–PEG–heparin/PBLA copolymers for targeted delivery of doxorubicin;Li;J Mater Chem,2011

5. Combination therapy: opportunities and challenges for polymer–drug conjugates as anticancer nanomedicines;Greco;Adv Drug Deliv Rev,2009

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