In vitro and in vivo tissue selectivity profile of solifenacin succinate (YM905) for urinary bladder over salivary gland in rats

Author:

Ohtake Akiyoshi,Ukai Masashi,Hatanaka Toshiki,Kobayashi Seiji,Ikeda Ken,Sato Shuichi,Miyata Keiji,Sasamata Masao

Publisher

Elsevier BV

Subject

Pharmacology

Reference28 articles.

1. Muscarinic receptor stimulation of phosphoinositide hydrolysis in the human isolated urinary bladder;Andersson;J. Urol.,1991

2. Functional diversity of muscarinic receptor subtypes in cellular signal transduction and growth;Ashkenazi;Trends Pharmacol. Sci.,1989

3. Prejunctional M1 facilitatory and M2 inhibitory muscarinic receptors mediate rat bladder contractility;Braverman;Am. J. Physiol.,1998

4. YM905: results of a randomised, double-blind placebo-controlled trial in patients with symptomatic overactive bladder;Cardozo;Eur. Urol.,2003

5. YM905 appears effective and well tolerated in patients with symptomatic idiopathic detrusor overactivity in a european placebo-and tolterodine-controlled, phase-II, dose-finding study;Chapple;Neurourol. Urodyn.,2002

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