(2S,2′R)-Analogue of LG190178 is a major active isomer-Reference-Cited by-同舟云学术

(2S,2′R)-Analogue of LG190178 is a major active isomer

Published:2008-01 Issue:1 Volume:18 Page:120-123
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Hakamata Wataru,Sato Yukiko,Okuda Haruhiro,Honzawa Shinobu,Saito Nozomi,Kishimoto Seishi,Yamashita Atsushi,Sugiura Takayuki,Kittaka Atsushi,Kurihara Masaaki

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference20 articles.

1. The Crystal Structure of the Nuclear Receptor for Vitamin D Bound to Its Natural Ligand

2. A Concise and Efficient Route to 2α-(ω-Hydroxyalkoxy)-1α,25-dihydroxyvitamin D3: Remarkably High Affinity to Vitamin D Receptor1

3. Synthesis, Biological Evaluation, and Conformational Analysis of A-Ring Diastereomers of 2-Methyl-1,25-dihydroxyvitamin D3 and Their 20-Epimers: Unique Activity Profiles Depending on the Stereochemistry of the A-Ring and at C-20

4. Synthesis and biological evaluation of all A-ring stereoisomers of 5,6-trans-2-methyl-1,25-dihydroxyvitamin D3 and their 20-epimers: possible binding modes of potent A-ring analogues to vitamin D receptor

5. Efficient and Versatile Synthesis of Novel 2α-Substituted 1α,25-Dihydroxyvitamin D3 Analogues and Their Docking to Vitamin D Receptors

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