1. From the Department of Anesthesiology, University of Colorado School of Medicine, Aurora, Colorado (T.K.H.); the Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado, Aurora, Colorado (T.K.H.); the Department of Psychiatry, Division of Substance Dependence, University of Colorado School of Medicine, Aurora, Colorado (S.K.M.-G.); and