Doxapram-mediated Increase in Cardiac Output Reduces Opioid Plasma Concentrations: A Pharmacokinetic/Pharmacodynamic-Pharmacokinetic/Pharmacodynamic Modeling Study in Healthy Volunteers-Reference-Cited by-同舟云学术

Doxapram-mediated Increase in Cardiac Output Reduces Opioid Plasma Concentrations: A Pharmacokinetic/Pharmacodynamic-Pharmacokinetic/Pharmacodynamic Modeling Study in Healthy Volunteers

Published:2017-03-25 Issue:1 Volume:102 Page:115-122
ISSN:0009-9236
Container-title:Clinical Pharmacology & Therapeutics
language:en
Short-container-title:Clin. Pharmacol. Ther.

Author:

Roozekrans M¹,Olofsen E¹,van der Schrier R¹,Boom M¹,Mooren R¹,Dahan A¹

Affiliation:

1. Department of Anesthesiology; Leiden University Medical Center; Leiden The Netherlands

Funder

Galleon Pharmaceuticals Corp.

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Reference22 articles.

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4. The ventilatory stimulant doxapram inhibits TASK Tandem Pore (K2P) potassium channel function but does not affect minimum alveolar anesthetic concentration;Cotten;Anesth. Analg.,2006

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