Gut microbiota from patients with arteriosclerotic CSVD induces higher IL-17A production in neutrophils via activating RORγt-Reference-Cited by-同舟云学术

Gut microbiota from patients with arteriosclerotic CSVD induces higher IL-17A production in neutrophils via activating RORγt

Published:2021-01-22 Issue:4 Volume:7 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Cai Wei¹²³^ORCID,Chen Xiaodong¹^ORCID,Men Xuejiao¹,Ruan Hengfang¹^ORCID,Hu Mengyan¹,Liu Sanxin¹,Lu Tingting¹,Liao Jinchi¹^ORCID,Zhang Bingjun¹,Lu Danli¹,Huang Yinong¹,Fan Ping¹^ORCID,Rao Junping⁴,Lei Chunyan⁵,Wang Jihui⁶,Ma Xiaomeng¹^ORCID,Zhu Qiang¹,Li Lili¹^ORCID,Zhu Xiuyun¹^ORCID,Hou Yujiao⁴,Li Shu⁴,Dong Qing¹^ORCID,Tian Qing¹,Ai Lulu¹,Luo Wenjing¹,Zuo Mengyun¹,Shen Liping¹,Xie Congyan¹,Song Hongzhong⁴,Xu Ganlin⁵,Zheng Kangdi⁵^ORCID,Zhang Zhao⁵,Lu Yongjun⁷,Qiu Wei¹,Chen Tao⁵⁸^ORCID,Xiang Andy Peng¹³^ORCID,Lu Zhengqi¹^ORCID

Affiliation:

1. Department of Neurology, Mental and Neurological Disease Research Center, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China.

2. Center of Clinical Immunology, Mental and Neurological Disease Research Center, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China.

3. Center for Stem Cell Biology and Tissue Engineering, Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Sun Yat-Sen University, Guangzhou 510080, China.

4. Department of Neurology, Yuedong Hospital, the Third Affiliated Hospital of Sun Yat-sen University, Meizhou, Guangdong 514011, China.

5. South China Institute of Biomedicine, Guangzhou, Guangdong 510535, China.

6. Department of Psychiatry, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510630, China.

7. Run Ze Laboratory for Gastrointestinal Microbiome Study, School of Life Sciences and Biomedical Center of Sun Yat-sen University, Guangzhou, Guangdong 510275, China.

8. Center of Human Microecology Engineering and Technology of Guangdong Province, Guangzhou, Guangdong 510535, China.

Abstract

Dysbiosis of gut microbiota might promote the pathophysiological process of aCSVD.

Funder

National Outstanding Youth Science Fund Project of National Natural Science Foundation of China

National Natural Science Foundation of China

Guangzhou Science and Technology Program key projects

Science and Technology Program of Guangzhou

China Postdoctoral Science Foundation Grant

Guangzhou Science and Technology Plan Project

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference53 articles.

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