Sodium rutin ameliorates Alzheimer’s disease–like pathology by enhancing microglial amyloid-β clearance-Reference-Cited by-同舟云学术

Sodium rutin ameliorates Alzheimer’s disease–like pathology by enhancing microglial amyloid-β clearance

Published:2019-02 Issue:2 Volume:5 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Pan Rui-Yuan¹²³^ORCID,Ma Jun³^ORCID,Kong Xiang-Xi³,Wang Xiao-Feng⁴,Li Shuo-Shuo¹²³,Qi Xiao-Long¹²³,Yan Yu-Han⁵,Cheng Jinbo³,Liu Qingsong⁶^ORCID,Jin Wanzhu⁷,Tan Chang-Heng⁴^ORCID,Yuan Zengqiang³⁸^ORCID

Affiliation:

1. The State Key Laboratory of Brain and Cognitive Sciences, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.

2. The College of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049, China.

3. The Brain Science Center, Beijing Institute of Basic Medical Sciences, Beijing 100850, China.

4. Department of Natural Medicinal Chemistry, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.

5. Department of Physiology, Dalian Medical University, Dalian 116044, China.

6. High Magnetic Field Laboratory, Chinese Academy of Sciences, Hefei, Anhui, 230031, China.

7. Key Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.

8. Center of Alzheimer’s Disease, Beijing Institute for Brain Disorders, Beijing 100069, China.

Abstract

Saltified rutin enhances microglial Aβ clearance, providing a potential therapeutic avenue for Alzheimer’s disease treatment.

Funder

National Nature Science Foundation of China

Beijing Nature Science Foundation

Beijing Innovation Program

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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