The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics-Reference-Cited by-同舟云学术

The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics

Published:2002-07-19 Issue:5580 Volume:297 Page:353-356
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Hardy John¹,Selkoe Dennis J.²

Affiliation:

1. Laboratories of Neurogenetics, National Institute on Aging, Bethesda, MD 20892, USA.

2. Center for Neurologic Diseases, Harvard Medical School, Brigham and Women's Hospital, Boston, MA 02115, USA.

Abstract

It has been more than 10 years since it was first proposed that the neurodegeneration in Alzheimer's disease (AD) may be caused by deposition of amyloid β-peptide (Aβ) in plaques in brain tissue. According to the amyloid hypothesis, accumulation of Aβ in the brain is the primary influence driving AD pathogenesis. The rest of the disease process, including formation of neurofibrillary tangles containing tau protein, is proposed to result from an imbalance between Aβ production and Aβ clearance.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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