The chemerin-CMKLR1 axis limits thermogenesis by controlling a beige adipocyte/IL-33/type 2 innate immunity circuit

Author:

Lin Yuli1ORCID,Xiao Liuling23ORCID,Cai Qian1ORCID,Zhu Cuisong2ORCID,Li Shufen2ORCID,Li Bingji1ORCID,Liu Ting1ORCID,Zhang Qiongyue4ORCID,Wang Yi4ORCID,Li Yiming4ORCID,He Xing5ORCID,Pan Dongning2ORCID,Tang Qiqun2ORCID,Wu Xiaohui6ORCID,Pan Weiqing5ORCID,Wang Jiqiu7ORCID,Li Xi8ORCID,He Rui19ORCID

Affiliation:

1. Department of Immunology and Key Laboratory of Medical Molecular Virology of Ministries of Education and Health, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China.

2. Key Laboratory of Metabolic Molecular Medicine, Ministry of Education, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China.

3. Center for Translational Research in Hematologic Malignancies, Houston Methodist Cancer Center, Houston Methodist Research Institute, Houston, TX 77030, USA.

4. Division of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai 200040, China.

5. Department of Tropical Diseases, Naval Medical University, Shanghai 200433, PR China.

6. State Key Laboratory of Genetic Engineering and National Center for International Research of Development and Disease, Institute of Developmental Biology and Molecular Medicine, Collaborative Innovation Center of Genetics and Development, School of Life Sciences, Fudan University, Shanghai 200433, China.

7. Shanghai National Clinical Research Center for Metabolic Diseases, Department of Endocrinology and Metabolism, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine (SJTUSM), Shanghai 200025, China.

8. Biology Science Institutes, Chongqing Medical University, Chongqing 400032, China.

9. National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai 200040, China.

Abstract

Chemerin restricts cold-induced IL-33 production by beige adipocytes, impairing beige fat’s ability to dissipate excess energy stores.

Funder

Science and Technology Innovation Plan Of Shanghai Science and Technology Commission

The National Key Research and Development Program of China

the National Natural Science Foundation of China grant

Major Special Projects of the Ministry of Science and Technology

National natural Science Foundation of China’s major research project

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine,Immunology

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