Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance
Author:
Publisher
Springer Science and Business Media LLC
Subject
General Biochemistry, Genetics and Molecular Biology,General Medicine
Link
http://www.nature.com/articles/nm.3760.pdf
Reference50 articles.
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2. Lee, F.Y., Lee, H., Hubbert, M.L., Edwards, P.A. & Zhang, Y. FXR, a multipurpose nuclear receptor. Trends Biochem. Sci. 31, 572–580 (2006).
3. Repa, J.J. et al. Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimers. Science 289, 1524–1529 (2000).
4. Zollner, G. et al. Role of nuclear bile acid receptor, FXR, in adaptive ABC transporter regulation by cholic and ursodeoxycholic acid in mouse liver, kidney and intestine. J. Hepatol. 39, 480–488 (2003).
5. Fang, S. et al. The p300 acetylase is critical for ligand-activated farnesoid X receptor (FXR) induction of SHP. J. Biol. Chem. 283, 35086–35095 (2008).
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