Differential requirement for the Polycomb repressor complex 2 in dendritic cell and tissue-resident myeloid cell homeostasis

Author:

Zhan Yifan123ORCID,Zhang Yuxia124ORCID,Zhang Shengbo12ORCID,Coughlan Hannah12ORCID,Baldoni Pedro L.12ORCID,Jacquelot Nicolas12ORCID,Cao Wang H.J.12ORCID,Preston Simon12ORCID,Louis Cynthia12ORCID,Rautela Jai5,Pellegrini Marc12,Wicks Ian P.12,Alexander Warren S.12,Harrison Leonard C.12ORCID,Lew Andrew M.126,Smyth Gordon K.17ORCID,Nutt Stephen L.12ORCID,Chopin Michaël12ORCID

Affiliation:

1. Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3052, Australia.

2. Department of Medical Biology, University of Melbourne, Parkville, VIC 3010, Australia.

3. Drug Discovery, Shanghai Huaota Biopharma, Shanghai, China.

4. Guangzhou Institute of Pediatrics, Guangzhou Women and Children’s Medical Center, State Key Laboratory of Respiratory Diseases, Guangzhou Medical University, Guangzhou, Guangdong 510623, China.

5. Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia.

6. Department of Microbiology and Immunology, University of Melbourne, Parkville, VIC 3010, Australia.

7. School of Mathematics and Statistics, University of Melbourne, Parkville, VIC 3010, Australia.

Abstract

PRC2 is essential for the self-renewal of tissue-resident macrophages but dispensable for dendritic cell development and function.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine,Immunology

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