Mutation rate and genotype variation of Ebola virus from Mali case sequences-Reference-Cited by-同舟云学术

Mutation rate and genotype variation of Ebola virus from Mali case sequences

Published:2015-04-03 Issue:6230 Volume:348 Page:117-119
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Hoenen T.¹,Safronetz D.¹,Groseth A.¹,Wollenberg K. R.²,Koita O. A.³,Diarra B.³,Fall I. S.⁴,Haidara F. C.⁵,Diallo F.⁵,Sanogo M.³,Sarro Y. S.³,Kone A.³,Togo A. C. G.³,Traore A.⁵,Kodio M.⁵,Dosseh A.⁶,Rosenke K.¹,de Wit E.¹,Feldmann F.⁷,Ebihara H.¹,Munster V. J.¹,Zoon K. C.⁸,Feldmann H.¹,Sow S.⁵

Affiliation:

1. Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Hamilton, MT 59840, USA.

2. Bioinformatics and Computational Biosciences Branch, NIAID, NIH, Bethesda, MD 20892, USA.

3. Center of Research and Training for HIV and Tuberculosis, University of Science, Technique and Technologies of Bamako, Mali.

4. World Health Organization Office, Bamako, Mali.

5. Centre des Operations d’Urgence, Centre pour le Développement des Vaccins (CVD-Mali), Centre National d’Appui à la lutte contre la Maladie, Ministère de la Sante et de l’Hygiène Publique, Bamako, Mali.

6. World Health Organization Inter-Country Support Team, Ouagadougou, Burkina Faso.

7. Rocky Mountain Veterinary Branch, Division of Intramural Research, NIAID, NIH, Hamilton, MT 59840, USA.

8. Office of the Scientific Director, NIAID, NIH, Bethesda, MD 20895, USA.

Abstract

Evolution in the Ebola virus outbreak Has rapid mutation produced alarming new virus characteristics in the 2013–2015 Ebola virus outbreak in West Africa? Hoenen et al. sequenced isolates obtained 9 months into the epidemic from cases in Mali. The nucleotide substitution rate was consistent with rates estimated from past Central African outbreaks. In contrast, analysis of sequence data from early in the outbreak indicated rapid mutation. This more recent finding offers confidence that diagnostic methods, vaccines, and other treatment interventions will remain effective. Nevertheless, vigilance must be maintained: A few mutations can radically change the biological properties of other RNA viruses. Science , this issue p. 117

Funder

NIH

NIAID

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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