Genomic surveillance elucidates Ebola virus origin and transmission during the 2014 outbreak-Reference-Cited by-全球学者库

Genomic surveillance elucidates Ebola virus origin and transmission during the 2014 outbreak

Published:2014-09-12 Issue:6202 Volume:345 Page:1369-1372
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Gire Stephen K.¹²,Goba Augustine³,Andersen Kristian G.¹²,Sealfon Rachel S. G.²⁴,Park Daniel J.²,Kanneh Lansana³,Jalloh Simbirie³,Momoh Mambu³⁵,Fullah Mohamed³⁵,Dudas Gytis⁶,Wohl Shirlee¹²⁷,Moses Lina M.⁸,Yozwiak Nathan L.¹²,Winnicki Sarah¹²,Matranga Christian B.²,Malboeuf Christine M.²,Qu James²,Gladden Adrianne D.²,Schaffner Stephen F.¹²,Yang Xiao²,Jiang Pan-Pan¹²,Nekoui Mahan¹²,Colubri Andres¹,Coomber Moinya Ruth³,Fonnie Mbalu³,Moigboi Alex³,Gbakie Michael³,Kamara Fatima K.³,Tucker Veronica³,Konuwa Edwin³,Saffa Sidiki³,Sellu Josephine³,Jalloh Abdul Azziz³,Kovoma Alice³,Koninga James³,Mustapha Ibrahim³,Kargbo Kandeh³,Foday Momoh³,Yillah Mohamed³,Kanneh Franklyn³,Robert Willie³,Massally James L. B.³,Chapman Sinéad B.²,Bochicchio James²,Murphy Cheryl²,Nusbaum Chad²,Young Sarah²,Birren Bruce W.²,Grant Donald S.³,Scheiffelin John S.⁸,Lander Eric S.²⁷⁹,Happi Christian¹⁰,Gevao Sahr M.¹¹,Gnirke Andreas²,Rambaut Andrew⁶¹²¹³,Garry Robert F.⁸,Khan S. Humarr³,Sabeti Pardis C.¹²

Affiliation:

1. Center for Systems Biology, Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA.

2. Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.

3. Kenema Government Hospital, Kenema, Sierra Leone.

4. Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

5. Eastern Polytechnic College, Kenema, Sierra Leone.

6. Institute of Evolutionary Biology, University of Edinburgh, Edinburgh EH9 3JT, UK.

7. Systems Biology, Harvard Medical School, Boston, MA 02115, USA.

8. Tulane University Medical Center, New Orleans, LA 70112, USA.

9. Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

10. Redeemer’s University, Ogun State, Nigeria.

11. University of Sierra Leone, Freetown, Sierra Leone.

12. Fogarty International Center, National Institutes of Health, Bethesda, MD 20892, USA.

13. Centre for Immunity, Infection and Evolution, University of Edinburgh, Edinburgh EH9 3JT, UK.

Abstract

Evolution of Ebola virus over time The high rate of mortality in the current Ebola epidemic has made it difficult for researchers to collect samples of the virus and study its evolution. Gire et al. describe Ebola epidemiology on the basis of 99 whole-genome sequences, including samples from 78 affected individuals. The authors analyzed changes in the viral sequence and conclude that the current outbreak probably resulted from the spread of the virus from central Africa in the past decade. The outbreak started from a single transmission event from an unknown animal reservoir into the human population. Two viral lineages from Guinea then spread from person to person into Sierra Leone. Science , this issue p. 1369

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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