A Strategy for Modulation of Enzymes in the Ubiquitin System-Reference-Cited by-同舟云学术

A Strategy for Modulation of Enzymes in the Ubiquitin System

Published:2013-02 Issue:6119 Volume:339 Page:590-595
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Ernst Andreas¹,Avvakumov George²,Tong Jiefei³,Fan Yihui⁴,Zhao Yanling⁴,Alberts Philipp³,Persaud Avinash³⁵,Walker John R.²,Neculai Ana-Mirela¹,Neculai Dante²,Vorobyov Andrew¹,Garg Pankaj¹,Beatty Linda¹,Chan Pak-Kei⁶,Juang Yu-Chi⁷,Landry Marie-Claude⁷,Yeh Christina⁷⁸,Zeqiraj Elton⁷,Karamboulas Konstantina¹,Allali-Hassani Abdellah²,Vedadi Masoud²,Tyers Mike⁶⁷,Moffat Jason¹⁸⁹¹⁰,Sicheri Frank⁷⁸,Pelletier Laurence⁷⁸,Durocher Daniel⁷⁸,Raught Brian¹⁰,Rotin Daniela³⁵,Yang Jianhua⁴,Moran Michael F.³⁸⁹,Dhe-Paganon Sirano²¹¹,Sidhu Sachdev S.¹⁸⁹¹⁰

Affiliation:

1. Terrence Donnelly Center for Cellular and Biomolecular Research, University of Toronto, 160 College Street, Toronto, Ontario M5S 3E1, Canada.

2. Structural Genomics Consortium, MaRS Centre, 101 College Street, Suite 700, Toronto, Ontario M5G 1L7, Canada.

3. Hospital for Sick Children, 101 College Street, Toronto, Ontario M5G 1L7, Canada.

4. Texas Children's Cancer Center, Department of Pediatrics, Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA.

5. Biochemistry Department, University of Toronto, Toronto, Ontario M5S 3E1, Canada.

6. Institut de Recherche en Immunologie et Cancérologie, Université de Montréal, Montreal, Quebec H3C 3J7, Canada.

7. Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario M5G 1X5, Canada.

8. Department of Molecular Genetics, University of Toronto, 160 College Street, Toronto, Ontario M5S 3E1, Canada.

9. Banting and Best Department of Medical Research, University of Toronto, 160 College Street, Toronto, Ontario M5S 3E1, Canada.

10. Ontario Cancer Institute and McLaughlin Centre for Molecular Medicine, University of Toronto, 101 College Street, Toronto, Ontario M5G 1L7, Canada.

11. Department of Physiology, University of Toronto, 101 College Street, Toronto, Ontario M5G 1L7, Canada.

Abstract

Modifying Deubiquitinases Protein ubiquitination is a widespread mechanism for cellular regulation, and new regulators are valuable research tools and may help to generate therapeutic small molecules. Ernst et al. (p. 590 , published online 3 January) used known crystal structures to roughly define the interaction domain between a ubiquitin-specific protease and a ubiquitinated substrate and then screened ubiquitin variants with changes in these residues to find variants that acted as potent and specific regulators that could modify ubiquitin pathway regulation in cells.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference69 articles.

1. Will the Ubiquitin System Furnish as Many Drug Targets as Protein Kinases?

2. The emerging complexity of protein ubiquitination

3. The Ubiquitin Code

4. A Genomic and Functional Inventory of Deubiquitinating Enzymes

5. Targeting the ubiquitin-proteasome system for cancer therapy

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