Affiliation:
1. Department of Molecular Biology, Research Institute of Scripps Clinic, La Jolla, CA 92037.
Abstract
The specific hydrolysis of unactivated esters bearing an
R
or
S
enantiomeric alcohol has been achieved by two separate classes of catalytic antibodies induced to bind either the
R
or
S
substrates. The antibodies exhibit rate accelerations (10
3
) to 10
5
) above background hydrolysis that, coupled with their antipodal specificity, provide a novel set of reagents for use in synthesis.
Publisher
American Association for the Advancement of Science (AAAS)
Reference43 articles.
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