Direct Chiral Separation of Binaphthyl Derivatives Using Atroposelective Antibodies-Reference-Cited by-同舟云学术

Direct Chiral Separation of Binaphthyl Derivatives Using Atroposelective Antibodies

Published:2017-03-23 Issue:9 Volume:2 Page:2622-2625
ISSN:2365-6549
Container-title:ChemistrySelect
language:en
Short-container-title:ChemistrySelect

Author:

Adachi Takuma¹,Odaka Tomoki¹,Harada Akira²³,Yamaguchi Hiroyasu¹^ORCID

Affiliation:

1. Department of Macromolecular Science, Graduate School of Science Osaka University, Toyonaka Osaka 560-0043 Japan

2. Project Research Center for Fundamental Sciences, Graduate School of Science Osaka University, Toyonaka Osaka 560-0043 Japan

3. JST-ImPACT Chiyoda-ku Tokyo 100-8914 Japan

Abstract

AbstractA simple procedure for chiral separation based on the difference in the molecular weights of the antigen‐antibody complex and analyte is developed. We raise monoclonal antibodies (mAbs) highly specific for the R‐ or S‐isomer of a binaphthyl derivative (BN) by immunizing mice with the corresponding BN enantiomer. Aqueous solutions of racemic BN are mixed with mAbs. The free BN is separated by ultrafiltration. The enantiomers of BN are obtained with a high e.e. using atroposelective antibodies.

Funder

JSPS KAKENHI

Publisher

Wiley

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1002/slct.201700231/fullpdf

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