Unmasking immune suppression-Reference-Cited by-同舟云学术

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Unmasking immune suppression

Published:2024-07-12 Issue:6705 Volume:385 Page:140-142
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Pitarresi Jason R.¹,Fitzgerald Katherine A.²

Affiliation:

1. Division of Hematology-Oncology, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.

2. Division of Innate Immunity, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.

Abstract

Inhibition of a mutated metabolic enzyme puts the sting back in antitumor immunity

Publisher

American Association for the Advancement of Science (AAAS)

Link

https://www.science.org/doi/pdf/10.1126/science.adq5196

Reference15 articles.

1. Suppression of antitumor T cell immunity by the oncometabolite (R)-2-hydroxyglutarate

2. Mutant-IDH inhibits Interferon-TET2 signaling to promote immunoevasion and tumor maintenance in cholangiocarcinoma

3. Isocitrate dehydrogenase mutations suppress STAT1 and CD8+ T cell accumulation in gliomas

4. Mutant IDH1 regulates the tumor-associated immune system in gliomas

5. Oncometabolite d -2HG alters T cell metabolism to impair CD8 ⁺ T cell function

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